On August 14th, the College organized a lecture featuring Professor Keqiang Ye from the Shenzhen Institute of Advanced Technology. The topic of the lecture was "Pathogenesis and Early Diagnosis of Alzheimer's Disease." The lecture focused on the critical role of the C/EBPb/AEP signaling pathway in the development and progression of Alzheimer's disease and Parkinson's disease.

Professor Ye's research has discovered a protease called asparagine endopeptidase (AEP), which cleaves amyloid precursor protein (APP) and tau protein in the brain, leading to the formation of harmful aggregates and the neurodegeneration and cognitive symptoms observed in Alzheimer's disease patients. His laboratory has also identified several small molecule inhibitors of AEP, which show great potential for the treatment of Alzheimer's disease. In Parkinson's disease, his team has recently developed α-synuclein markers that can be used as early detection tools and are currently being tested in clinical studies.

The discovery of AEP by Professor Ye has helped researchers understand the role of abnormal protein aggregation in the development of Alzheimer's disease and Parkinson's disease, providing a potential target for intervention therapies. AEP can also serve as a biomarker for diagnosing the diseases and monitoring their progression. Overall, Professor Ye's research highlights the potential key role of AEP in the early diagnosis of neurodegenerative diseases and deepens our understanding of the pathological features of Alzheimer's disease and Parkinson's disease.

Professor Ye is an internationally recognized authority in the field of neurodegenerative diseases and drug development. He currently serves as the Chair and Professor of the Department of Biology at the School of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences.

The College is committed to promoting exchange and interaction with top scientists to enhance our understanding of complex diseases and facilitate the development of innovative medical solutions.