,Mr. & Mrs. Ko Chi Ming Centre for Parkinson's Disease Research Hong Kong Baptist University

Professor, Director of Mr. & Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research.

Program Director of BCM & BSc. BIOMED, Teaching & Research Division, Associate Director of Clinical Division.

Expert in Chinese Medicine, Pharmacology of Chinese Medicine, Neurodegenerative Diseases.

limin@hkbu.edu.hk

Prof. LI Min obtained her Bachelor's degree from the Henan University of Traditional Chinese Medicine (TCM), China, in 1985, her Master's degree in Chinese Medicine at the Guangzhou University of Chinese Medicine, China, in 1988 and her PhD degree in Cardiology at the School of Medicine, Tokai University, Japan, in 2001. Then she joined the School of Chinese Medicine, Hong Kong Baptist University, where she is currently a professor and serves as the Programme Director of BCM, an Associate Director of the Clinical Division and the Director of Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research. Prof. LI received an Award of the Distinguished Female Chinese Medicine Practitioner by the China Association of Chinese medicine in 2007, School’s Award for Outstanding Performance in Scholarly Work in 2012 and President’s Award for Outstanding Performance in Teaching from Hong Kong Baptist University in 2013. Prof. LI’s clinical specialty is in Chinese medicine treatment of neurodegenerative diseases, including Parkinson's disease (PD), Alzheimer's disease (AD) and vascular dementia (VD), as well as on cardio-cerebrovascular diseases.

Prof. LI’s long-term research interests are:

● Neurodegenerative Diseases Including Parkinson’s disease (PD) and Alzheimer’s Disease (AD).

● Chinese Herbal Medicine for Prevention and Treatment of Neurodegenerative Diseases.

● Development of Molecular Targets for Drug Discovery from TCM for Neurodegenerative Diseases.

Prof. LI’s current research directions are:

● Investigation of the Efficacy and Safety of TCM in the Treatment of Neurodegenerative Diseases including PD and AD based on Randomized Controlled Clinical Trials, as well as the Interaction of TCM and Western Medicine.

● Understanding the Neuroprotective Effects and Underlying Mechanisms of TCM on Neurodegenerative Diseases including PD and AD.

Principal Investigator

_{Prof. Min Li (M.D. & Ph.D.)}

Associate Dean of School of Chinese Medicine;

Professor, Teaching and Research Division;

Program Director of Bachelor of Chinese Medicine & Bachelor of Science (Hons) in Biomedical Science and Master of Chinese Medicine programmes;

Director of Mr. and Mrs. Ko Chi Ming Centre for Parkinson's Disease Research

Chinese Medicine, Neurodegenerative Diseases, Cardiovascular Diseases,

Pharmacology, and Randomized Controlled Clinical Trials

E-mail: limin@hkbu.edu.hk

Prof. Cheung.jpg

Dr. King-ho Cheung (Ph.D.)

Associate Professor

Academic Sectary of CPDR
Lysosomal Ca²⁺ and pH regulation; Neurodegenerative diseases; Calcium singling;

Chinese Medicine
E-mail: kingho@hkbu.edu.hk

Visiting Assistant Professors

Dr. Ju-Xian Song (Ph.D.)

Visiting Assistant Professor

Neurodegenerative Diseases, Autophagy & Lysosome Regulation, Neuroprotection,

Molecular Pharmacology, and Chinese Medicine

E-mail: juxian.song@gmail.com

Research Assistant Professors

Dr. Ben.jpg

Dr. Benjamin Chun-Kit Tong (Ph.D.)

Research Assistant Professor

Autophagy dysregulation in neuronal disease, Calcium Signaling, Calcium Channelopathies,

Molecular Biology, and Chinese Medicine

E-mail: cktong@hkbu.edu.hk

Dr. Ashok.png

Dr. Ashock Iyaswamy (Ph.D.)

Research Assistant Professor

Neurodegenerative diseases, Molecular Pharmacology, and Chinese Medicine

E-mail: ashokenviro@gmail.com

Ph.D. Students

Mr. Sravan Godalakrishna

Research Assistant

Neurodegenerative diseases, Neuroprotection, and Molecular Pharmacology

E-mail: sravangs@gmail.com

Ms. Zhou Zhu

PhD student

Autophagy Regulation, Neuroprotection, and Neurodegenerative Diseases

E-mail: zzhou1022@gmail.com

Mr. Aston Jia-xi Wu

PhD Student

Autophagy & Mitophagy Regulation, Calcium Channel, and Chinese Medicine

Email: astonwu94@gmail.com

Ms. Alexis Shiying Huang

Ph.D. Student

Neurodegenerative Diseases, Calcium singling, and Chinese Medicine

Email: cszhsy@gmail.com

Research Staff

Dr. K. Senthilkumar (Ph.D.)

Senior Research Assistant

Neurodegenerative diseases; Neuroprotection; and Molecular Pharmacology

E-mail: senthilnslab@gmail.com

Dr. Sandeep Malampati (Ph.D.)

Senior Research Assistant

Neurodegenerative diseases, Neuroprotection, and Pharmacology

E-mail: deepu.pharma08@gmail.com

Mr. Jia Liu

Research Assistant

Neurodegenerative Disease, Molecular Pharmacology and Chinese medicine.

E-mail: liujiatheone@hotmail.com

Mr. Cheng-fu Su

Research Assistant

Neurodegenerative Disease, Diabetes disease and Chinese medicine.

E-mail: suchengfu@hkbu.edu.hk

Previous Lab Members

Prof. Fu-Long Liao

Prof. Dong Han

Dr. Chi-Ho Chung

Dr. Ming-Qi Zhao

Dr. Chi Zhao

Dr. Li-Xia Xie

Dr. Wan-Fung Kum

Dr. Jia-Hong Lu

Dr. Xing Yu

Mr. Wai-Leuk Fong

Ms. Yan Wang

Mr. Sui-Cheung Man

Mr. Yuan-Chi Lam

Ms. Yu Zeng

Ms. Zhong Nan Wu

Dr. Siva Sundara Kumar Durairajan

Dr. Ananth Pharma

Ms. Ying-Yu Huang

Ms. Mei-Xiang Li

Mr. Aun Raza

Dr. Jing-Yi Liu

Mr. Huan Zhang

Dr. Liang-Feng Liu

Dr. Chuan-Bin Yang

Dr. Zi-Ying Wang

Mr. Kaliyamurthy Venkatapathy

Ms. Anusha Nalluri

Funded Projects

Project 1	Title: Understanding the molecularmechanisms of Corynoxine B in promoting autophagy and neuroprotection: Targeting HMGB1-Beclin 1 interaction Principal Investigator: Prof. Min Li Funding Body: Hong Kong General Research Fund Project ID: RGC/HKBU-121009/14 Exercise Year: 2015/2016 Approved Project Duration:24 months Project Fund:HK$ 564,833

Project 2	Title: Combined Use of ChineseMedicine Decoction (Tianma Gouteng Yin) and Sinemet for the Treatment of Parkinson’s disease: Preclinical Evaluations on Safety and Efficacy Principal Investigator: Prof. Min Li Funding Body: Hong Kong Health and Medical Research Fund Project ID: HMRF/12132091 Exercise Year: 2015/2016 Approved Project Duration:24 months Project Fund:HK$ 999,600

Project 3	Title: Chemical modification of oxindole alkaloids from the Chinese herbal medicine Gouteng for the optimization of anti-Parkinson's disease activity Principal Investigator: Prof. Min Li Funding Body: Hong Kong Innovation and Technology Fund Project ID: ITS/274/12 Exercise Year: 2013/2015 Approved Project Duration: 18 months Project Fund:HK$ 999,925

Project 4	Title: Functional Analysis of Isorhynchophylline in Promoting Autophagy and Protecting Neurons Principal Investigator: Prof. Min Li Funding Body: NSFC / RGC Joint Research Scheme Project ID: N_HKBU213/11 Exercise Year: 2012/2015 Approved Project Duration: 36 months Project Fund:HK$ 794,840

Project 5	Title: Chinese medicine for inflammatory bowel disease and Parkinson's disease: study about the efficacy and its underlying mechanism Principal Investigator: Prof. Min Li Funding Body: Interdisciplinary Research Matching Scheme of HKBU Project ID: HKBUIRMS/12-13/1A Exercise Year: 2012/2015 Approved Project Duration: 36 months Project Fund:HK$ 687,500

Project 6	Title: Natural Neuronal Autophagy Enhancer Schisandrin B: Molecular Targets and Neuroprotective Effects Principal Investigator: Prof. Min Li Funding Body: Faculty Research Grant of HKBU Project ID: HKBU/FRG II/13-14/094 Exercise Year: 2014/2015 Approved Project Duration: 12 months Project Fund:HK$ 120,000

Project 7	Title: Restoration of alpha-synuclein-mediated autophagy deficiency in Parkinson’s disease by natural autophagy inducers Principal Investigator: Prof. Min Li Funding Body: Faculty Research Grant of HKBU Project ID: HKBU/FRG II/12-13/038 Exercise Year: 2013/2014 Approved Project Duration: 12 months Project Fund:HK$ 135,000

Project 8	Title: Development of a mTOR-independent activator of TFEB for the treatment of neurodegenerative diseases Principal Investigator:Prof. Min Li Funding Body: Matching Proof-of-Concept Fund of HKBU Project ID: MPCF-008-2014/2015 Exercise Year: 2014/2015 Approved Project Duration: 12 months Project Fund:HK$ 200,000

Project 9	Title: Preclinical efficacy and safety evaluation of Corynoxine B for the treatment of Parkinson’s disease Principal Investigator: Prof. Min Li Funding Body: Matching Proof-of-Concept Fund of HKBU Project ID: MPCF-004-2012/2013 Exercise Year: 2013/2015 Approved Project Duration: 24 months Project Fund:HK$ 200,000

Project 10	Title: Development of a new drug from Chinese herbal medicine on treatment of Parkinson’s disease Principal Investigator: Prof. Min Li Funding Body: HKBU Project ID: SCM/10-11/03 Exercise Year: 2011/2014 Approved Project Duration: 36 months Project Fund:HK$ 300,000

Project 11	Title: Understanding the role of PI3K/AKT/GSK/β-catenin signaling in the neuroprotective effects of Berberine (BBR) on Aβ-induced tau phosphorylation and toxicity Principal Investigator: Prof. Min Li Funding Body: Faculty Research Grant of HKBU Project ID: HKBU/FRG II/11-12/094 Exercise Year: 2012/2013 Approved Project Duration: 12 months Project Fund:HK$ 120,000

Project 12	Title: Phosphoproteomic study of corynoxine, an alkaloid isolated from Chinese medicine Gouteng, on neuronal cell culture Principal Investigator: Prof. Min Li Funding Body: Faculty Research Grant of HKBU Project ID: HKBU/FRGI/11-12/035 Exercise Year: 2012/2013 Approved Project Duration: 12 months Project Fund:HK$ 40,000

Project 13	Title: 柯诺辛对帕金森病的神经保护作用及诱导神经细胞自噬的磷酸化蛋白调控网络研究 Principal Investigator: Prof. Min Li Funding Body: 深圳市科創委 Project ID: 深圳市未来产业发展专项资金（生命健康类）2014年第四批扶持计划03号 Exercise Year: 2015/2017 Approved Project Duration: Project Fund: RMB50,000

Project 14	Title: An In Vivo Investigation of The Therapeutic Effects of Modified Huang-Lian-Jie-Du-Tang and Its Combination With a Western Drug Principal Investigator: Dr. Durairajan Siva Sundara Kumar Funding Body: Hong Kong Health and Medical Research Fund Project ID: HMRF/11122511 Exercise Year: 2014/2016 Approved Project Duration: 24 months Project Fund:HK$ 904,000 Coordinator: Prof. Li Min

Project 15	Title: Structural modification of protopine alkaloid from the Chinese herbal medicine Yanhusuo for the optimization of anti-Alzheimer's disease activity Principal Investigator: Dr. Durairajan Siva Sundara Kumar Funding Body: Hong Kong Innovation and Technology Fund Project ID: ITFS/12132061 Exercise Year: 2014/2015 Approved Project Duration: 18 months Project Fund:HK$ 1,397,250 Coordinator: Prof. Li Min

Project 16	Title: Neuropharmacological and Chemical-genetic Approaches to Investigate the Therapeutic Effects of Yuanhu Zhitong Prescription in Treating Alzheimer’s Disease Principal Investigator: Dr. Durairajan Siva Sundara Kumar Funding Body: Hong Kong Innovation and Technology Fund Project ID: HMRF/12132061 Exercise Year: 2015/2016 Approved Project Duration: 24 months Project Fund:HK$ 884,000 Coordinator: Prof. Li Min

Project 17	Title: Development of NeuroDefend: A traditional Chinese medicine formula optimized for treating Alzheimer’s disease and other tauopathies. Principal Investigator: Dr. Durairajan Siva Sundara Kumar Funding Body: Hong Kong Innovation and Technology Fund Project ID: ITS/253/14 Exercise Year: 2015/2016 Approved Project Duration: 24 months Project Fund:HK$ 1,400,000 Coordinator: Prof. Li Min