• Biography
  • Research
  • Lab Members
  • Publications


Associate Professor, Teaching and Research Division

Expert in Pharmaceutical Formulation in Chinese Materia Medica and Drug Delivery System

yzhijun@hkbu.edu.hk

Dr Yang graduated at Shenyang Pharmaceutical University in 1986, after that he became a tutor and then lecturer in China Pharmaceutical University. During the period, he learned basic theories of Traditional Chinese Medicine at Nanjing University of Traditional Chinese Medicine, and conducted research in Gifu Pharmaceutical University in Japan as a visiting scholar. In 1993, he studied in Chiba University in Japan as a doctoral candidate, and obtained the PhD. in Pharmaceutical Science in 1997. Subsequently, Dr YANG assumed the duty of a researcher in TaiYo Pharmaceutical Industry Ltd in Japan. In 2000, he carried out his postdoctoral research in University of British Columbia, Canada. One year later, he served in Northern Lipids Inc. in Canada as a scientist to develop Liposome Formulation.





Dr Yang has been engaged in development and research in pharmaceutics for chemical and natural active pharmaceutical ingredients (API). He has attained remarkable results both in publications and pharmacy market products. Currently Dr Yang is focusing on the most front line research of the pharmaceutics to develop the formulation of API by combining the theories of Traditional Chinese Medicines (TCM) and Drug Delivery System (DDS).



Funded Projects


Project 1

Title: Immunoliposome delivery triptolide to lung cancer   enhanced by Carbonic Anhydrase IX Antibody 

Principal Investigator: Dr. Zhijun Yang (Ph.D.)

Funding Body: Hong Kong General Research Fund

Project ID: HKBU 12102514 

Exercise Year: 2015/2017

Approved Project Duration: 24 months 

Project Fund: HK$ 900,000 

Coordinator: ZhijuYang (Ph.D.) 



Project 2

Title: BFGC300 and BFGT 600 mg

Principal Investigator: Dr. Zhijun Yang (Ph.D.) 

Funding Body: Bright Future Pharmaceutical Laboratories

Project ID: HKBU BFPLL/13-14/01 

Exercise Year: 2014/2016 

Approved Project Duration: 24 months 

Project Fund: Confidential 

Coordinator: ZhijuYang (Ph.D.) 



Project 3

Title: Develop an emulsion-based formulation/nano-particle based formulation for Doxorubicin and Docetaxel

Principal Investigator: Dr. Zhijun Yang (Ph.D.) 

Funding Body: Kinex Pharmaceuticals 

Project ID: HKBU KP/13-14-01 

Exercise Year: 2014/2015

Approved Project Duration: 8 months 

Project Fund: confidential

Coordinator: ZhijuYang (Ph.D.)



 





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  Ms. Helena Ng Huei Leng (Ph.D.)


  Post-Doctoral Research Fellow

  Biochemistry & Physiology

  Email: hueilengng@yahoo.com






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  Mr. Zhang Jia-Yong


  Research Assistant

  Major: Chemistry

  Email: zhangjiayong-12@163.com







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  Mr. Jiahao-Li 


  Research Assistant

  Pharmaceutical Sciences in Chinese Medicine

  Traditional Chinese Pharmacology

  Email: 13433504@life.hkbu.edu.hk















1.      

Blenda Chi Kwan Wong, Hongqi Zhang, Ling Qin, Hubiao Chen, Chen Fang, Aiping Lu*Zhijun Yang*. Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro. Drug Design Development and Therapy. (in press)

2.      

Lin  Wang, Ai-Ping Lu, Zhi-Ling Yu, Ricky N. S. Wong, ZhaoXiang Bian, HoiHin  Kwok, Patrick YingKit Yue, LiMin Zhou, HuBiao Chen, Min Xu, Zhijun Yang*. The Melanogenesis-Inhibitory Effect and the Percutaneous Formulation of Ginsenoside Rb1. AAPS PharmSciTech (2014) DOI: 10.1208/s12249-014-0138-3

3.          

Tao Yi, Lin Zhu, Yi-Na Tang, Jian-Ye Zhang, Zhi-Tao Liang, Jun Xu, Zhong-Zhen Zhao, Zhi-Ling Yu, Zhao-Xiang Bian, Zhijun Yang, Hu-Biao Chen*.  An integrated strategy based on UPLC–DAD–QTOF-MS for metabolism and  pharmacokinetic studies of herbal medicines: Tibetan “Snow Lotus” herb  (Saussurea laniceps), a case study. Journal of Ethnopharmacology 153  (2014) 701–713

4.      

Ting TingXiao, Min   Xu, XiaoHong Yang, Lam Kok, Yeuk Lung Chow, Zhong ZhenZhao, Kelvin Sze-Yin   Leung, Zhijun Yang,  XiaoYing Tian, Zhi Li, Meng Yun Xin, Wei Xu. The evaluation on  embryotoxicity of Dipsaci Radix with mice and embryonic stem cells. Journal of Ethnopharmacology 151 (2014) 114–122

5.    

Baosheng Guo, Baoting Zhang, Lizhen Zheng, Tao Tang, Jin Liu, Heng Wu, Zhijun Yang, Songlin Peng, Xiaojuan He, Hongqi Zhang, Kevin K.M. Yue, Fuchu He, Lingqiang Zhang, Ling Qin, Zhaoxiang Bian, Weihong Tan, Zicai Liang, Aiping Lu*, Ge Zhang*. Therapeutic RNAi targeting CKIP-1 with cross-species sequence to stimulate bone. Bone, 59 (Feb.2014), 76–88 15; doi:10.1016/j.bone. 2013.,.

6.          

Yang Zhijun*,  Aiping Lu, Blenda Chi Kwan Wong, Xiaoyu Chen, Zhaoxiang Bian, Zhongzhen  Zhao, Wenhua   Huang, Ge Zhang, Hubiao Chen, Min Xu. Effect of  liposomes on the absorption   of water-soluble active pharmaceutical  ingredients via oral administration. Current Pharmaceutical Design 2013; 19 (37): 6647-54. PMID: 23621538   2013 Apr 23. [Epub ahead of print] [PubMed-as supplied by publisher].

7.    

Zhang M, Zang KH, Luo JL, Leung FP, Huang Y, Lin CY, Yang Zhijun, Lu AP, Tang XD, Xu HX, Sung JJ, Bian ZX. Magnolol  inhibits colonic   motility through down-regulation of  voltage-sensitive L-type Ca2+ channels of colonic smooth muscle cells in  rats. Phytomedicine. 2013 Aug 21. doi:pii: S0944-7113(13)00271-7.10.1016/j.phymed. 2013.07.008. [Epub ahead of print]; PMID:   23972358

8.    

Xiao HT, Tsang SW, Qin HY, Choi FF, Yang ZJ, Han QB, Chen HB, Xu HX, Shen H, Lu AP, Bian ZX. A bioactivity-guided study on the anti-diarrheal activity of Polygonum chinense Linn. J Ethnopharmacol. 2013 Sep 16;149(2):499-505. doi: 10.1016/j.jep. 2013.07.007. Epub 2013 Jul 26. PMID: 23895917

9.        

Xiaogang Wang,   Baosheng Guo, Qi Li, Jiang Peng, Yang Zhijun,  Aiyuan Wang,   Dong Li, Zhibo Hou, Ke Lv, Guanghan Kan, Heng Wu,  Jinping Song, Xiaohua Pan,   Qiao Sun, Shukuan Ling, Yuheng Li, Mu Zhu,  Pengfei Zhang, Songlin Peng, Xiaoqing Xie, An Hong, Ling Qin, Leungkim  Hung, Yinghui Li, Zhaoxiang Bian, Yanqiang Bai, Aiping Lu, Shanguang  Chen, Fuchu He, Ge Zhang*, Yingxian Li*.   miR-214 targets ATF4 to  inhibit bone formation. Nature Medicine. 19(1) 93-100 (JANUARY 2013)

      10.

Xiaoyu Chen, Wenhua Huang, Blenda Chi Kwan Wong, Linlin Yin, Yuen Fan Wong, Min Xu, Yang Zhijun*. Liposomes prolong the therapeutic effect of   anti-asthmatic medication via pulmonary delivery. International Journal of Nanomedicine. 2012; 7:1139-1148.

      11.

Zhu GY, Wong BC, Lu A, Bian ZX, Zhang G, Chen HB, Wong YF, Fong WF*, Yang Zhijun*. Alkylphenols from the Roots of Ardisia brevicaulis Induce G1 Arrest and Apoptosis through Endoplasmic Reticulum Stress Pathway in Human Non-small-cell Lung Cancer Cells. Chem Pharm Bull. 2012; 60(8):1029-36.

12.   

Min Xu*, Xiao Ying Tian, Kelvin Sze-Yin   Leung, Kam Cheong Lee, Tak Chong Chow, Bin Deng, Chi Ming Yiu, Chi I Chow, Zhong Zhen Zhao, Yang Zhijun,  Fong Wang Fun, Ting Ting Xiao, Wei Xu,   and Ping Xiang Deng.  Embryotoxicity of Psoralea corylifolia L.: in vivo and   in vitro  studies. Birth Defects   Research Part B: Developmental and Reproductive Toxicology. 2012; 95:386–394; DOI: 10.1002/bdrb.21028.

13.     

Ge Zhang*, Baosheng Guo, Heng Wu, Tao Tang, Baoting Zhang, Lizhen Zheng, Yixin   He, Yang Zhijun,  Xiaohua Pan, Heelum Chow, Kinwah To, Yaping Li, Dahu Li, Xinluan Wang,  Yixiang Wang, Kwongman Lee, Zhibo Hou, Nan Dong, Gang Li, Kwoksui Leung,  Leungkim Hung, Fuchu He, Lingqiang Zhang*, Ling Qin*. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nature Medicine. 2012; 18(2): 307-314.

14.   

He  Yi-Xin, Liu Zhong, Pan Xiao-Hua, Tang Tao,   Guo Bao-Sheng, Zhen  Li-zhen, Xie Xin-Hui, Wang Xin-Luan, Lee Kwong-Man, Li Gang, Cao  Yong-Ping, Wei Lei, Chen Yang, Yang Zhijun, Hung Leung-Kim, Qin Ling, Zhang Ge*. Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model. Osteoporosis International. 2012, 23:377–389 (DOI10.1007/s00198-011-1812-x).

15.   

Hiu-Yee Kwan, Yang Zhijun, Wang-Fun Fong, Yong-Mei Hu, Zhi-Ling Yu, Wen-Luan Wendy Hsiao*. The anticancer effect of oridonin is mediated by fatty acid   synthase suppression in human colorectal cancer cells, Journal of Gastroenterology. 2012, DOI10.1007/s00535- 012-0612-1.

16.   

Hiu Yee Kwan, Wang Fun Fong, Zhijun Yang, Zhi-Ling Yu* ,  Wen-Luan Wendy Hsiao*. Inhibition of DNA-dependent protein kinase  reduced palmitate and oleate-induced lipid accumulation in HepG2 cells. European Journal of Nutrition. 2012. DOI 10.1007/s00394- 012- 0467-5.

17.     

Tao Yi, Hongwing Lo, Zhongzhen Zhao, Zhiling Yu, Yang Zhijun and Hubiao Chen*.  Comparison of the Chemical Composition and Pharmacological Effects of  the   Aqueous and Ethanolic Extracts from a Tibetan “Snow Lotus” (Saussurea   laniceps) Herb. Molecules. 17, 7183-7194;   doi:10.3390/molecules17067183. 2012.

18.   

Hong-Yan Qin, Hai-Tao Xiao, Fung-Ping Leung, Yang Zhijun, Justin C. Y. Wu, Joseph J. Y. Sung, Hong-Xi Xu, Xu-Dong Tong, and Zhao-Xiang Bian*. JCM-16021,  a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in  TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing  Colonic EC Cell   Hyperplasia and Serotonin Availability in Rats. Evidence-Based Complementary and Alternative Medicine. 2012, Article ID 239638, 12 pages doi:10.1155/2012/239638.

19.   

Tao Yi, Yina Tang, Jianye Zhang, Zhongzhen Zhao, Yang Zhijun, Hubiao Chen*. Characterization and determination of six flavonoids in the ethnomedicine "Dragon's Blood" by UPLC-PAD-MS. Chemistry Central Journal. 2012; 6:116.

20.   

Shufang Nie, Wendy W L Hsiao, Weisan Pan, Yang Zhijun*.  Thermoreversible Pluronic® F127-based hydrogel containing liposomes for  the controlled delivery of paclitaxel: in vitro drug   release, cell  cytotoxicity and uptake studies. International Journal of Nanomedicin. 2011; 6: 151-166.

21.   

Xiao Ying Tian, Min Xu*, Bin Deng, Kelvin Sze-Yin Leung, King Fai Cheng, Zhong Zhen Zhao, Shi Ping Zhang, Yang Zhijun,  Ping Xiang Deng, Dong Ying Xu, Xiao Ping Xu, Irene Koo, Michael Wong.  The effects of Boehmeria nivea (L.) Gaud. on embryonic development: in  vivo and in vitro studies. Journal of Ethnopharmacology. 2011;   134: 393–398.

22.   

Wenhua Huang, Yang Zhijun*, Heng Wu,Yuenfan Wong, Zhongzhen Zhao, Liang Liu. Development of liposomal salbutamol dry powder inhaler formulation. Biological & Pharmaceutical Bulletin. 2010; 33(3): 512-517.

23.   

Lin ZX*, Jiao BW, Che CT, Zuo Z, Mok CF, Zhao M, Ho WKK, Tse WP, Lam KY, Fan RQ, Yang Zhijun,  Cheng CHK. Ethyl acetate fraction of the root of Rubia cordifolia L.  inhibits keratinocyte proliferation in vitro and promotes keratinocyte  differentiation in vivo: potential application for psoriasis treatment. Phytotherapy Research. 2010; 24(7): 1056-1064.

24.     

Yang Zhijun*,  David Fong, Linlin Yin, Yuenfan Wong, Wenhua Huang. Liposomes modulate  docetaxel-induced lipid oxidization and membrane damage in human  hepatoma cells. Journal of Liposome Research. 2009; 19(2): 122-130.

25.   

趙中振*(監修)、陳虎彪(監修)楊智鈞(監訳)中薬材鑑定図典、生薬の中国伝統評価技法、株式会社エヌティーエス、2012、東京

26.     

杨智钧*:中药透皮吸收制剂的设计与方法,侯世祥*主编, 现代中药制剂设计理论与实践pp.633-649, 人民卫生出版社,2010,北京



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