• Biography
  • Research
  • Lab Members
  • Publication



Associate Vice-President and Associate Director of Institute of Creativity, HKBU; Director and Chair Professor of Clinical Division, SCM

Expert in basic and clinical research of gastrointestinal disease with Chinese medicine

bzxiang@hkbu.edu.hk

Prof Bian Zhaoxiang had been educated in Nanjing University of Traditional Chinese Medicine (TCM), Beijing University of Traditional Chinese Medicine and Pharmacology and Guangzhou University of TCM, and was conferred the Ph.D. degree in Integrated Chinese and Western Medicine in 1994. After graduation, he engaged in clinical and basic research in digestive diseases in Guangzhou University of TCM. Under the Quality Migrant Admission Scheme of HKSAR, he moved to Hong Kong Baptist University in 2001. He has been awarded second prize of National Science and Technology Award of China in 1999. Currently, Prof Bian serves as Director of Clinical Division, School of Chinese Medicine, and Associate Vice-President of HKBU.




Prof Bian's research focuses mainly on the relationship between psychological stress and digestive diseases, especially focusing on the development and recurrence of irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and colorectal cancer. Major research topics involve: i) Basic mechanism of visceral hyperalgesia and gastrointestinal motility disorder and its associated depression; 2) Psychological stress and colorectal cancer; 3) Clinical trial with Chinese medicine for digestive diseases, including IBS, IBD, functional constipation and colorectal cancer ; 4). New drug development based on Chinese herbal medicine and its active fraction for digestive diseases.



Funded Projects


Project 1

Title: Effects of Combination of Berberine and 5-Aminosalicylate (5-ASA) Against Experimental Ulcerative Colitis 

and Its Potential Mechanisms 

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: Food and Health Bureau

Project ID: HMRF/12-13/01(Ref.#10111971)

Exercise Year: 2013/2014 

Approved Project Duration: 12 months 

Project Fund: HK$ 950,000

Coordinator: -

 

 

Project 2

Title: The effective fraction isolated from Radix Astragali Ameliorates Experimental ulcerative colitis by inhibiting 

MAPK pathways and NF-kB transcription

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: HKBU

Project ID: HKBU/FRG2/11-12/005

Exercise Year: 2012

Approved Project Duration: 12 months 

Project Fund: HK$120,000

Coordinator: --

 

 

Project 3

Title: Traditional Chinese Medicine for Inflammatory Bowel Disease: Efficacy Confirmation and Basic 

Mechanism Study

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: HKBU

Project ID: HKBU/IRMS

Exercise Year: 2012/2014

Approved Project Duration: -

Project Fund: HK$ 1,500,000

Coordinator: -

 

 

Project 4

Title: Development of Amyloid Fibrillation Inhibitors based on Small Molecules and Natural Products Derived from

 Chinese Herbal Medicine as a Treatment Approach for Alzheimer’s Disease

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: HKBU

Project ID: HKBU/IRMS

Exercise Year: 2012/2015

Approved Project Duration: -

Project Fund: HK$ 2,950,000

Coordinator: -


 

Project 5

Title: Raloxifene and Estrogen Block oxidative stress(HXXO)-induced alterations in proteome of

prostate endothelial cells

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: HKBU

Project ID: HKBU/FRG2/11-12/005

Exercise Year: 2012

Approved Project Duration: 12 months

Project Fund: HK$100,000

Coordinator: -

 

 

Project 6

Title: Chinese herbal medicine for functional constipation: a prospective double blinded 

double dummy randomized controlled study.

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: HHSRF, Health and Health Services Research Fund, Research Council, Hong Kong

Project ID: -

Exercise Year: 2012/2014

Approved Project Duration: -

Project Fund: HK$:996,600

Coordinator: -

 

 

Project 7

Title: Nerve-growth factor mediated enteric neuronal plasticity contributes to neonatal 

maternal separation-induced visceral hyperalgesia in rats.

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: Research Grants Council of Hong Kong

Project ID: -

Exercise Year: 2010/2012

Approved Project Duration: 24 months

Project Fund: HK$ 980,000

Coordinator: -

 

 

Project 8

Title: Research about methodology of Syndrome differentiation in Randomized controlled trial.

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: National Natural Science Foundation, China

Project ID: -

Exercise Year: 2012/2015

Approved Project Duration: -

Project Fund: RMB 600,000

Coordinator: -

 

 

Project 9

Title: Polygonum chinense Linn as an anti-diarrheal remedy in Traditional Chinese Medicine: 

from action substance to underlying mechanism

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: HKBU

Project ID: HKBU/FRG2/10-11/027

Exercise Year: 2011

Approved Project Duration: -

Project Fund: HK$120,000

Coordinator: -

 

 

Project 10

Title: Systematic review on the treatment of HBV and prevention of Liver Complications 

using Chinese herbal medicine

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: Hospital Authority of Hong Kong

Project ID: -

Exercise Year: 2009/2010

Approved Project Duration: -

Project Fund: HK$229,260

Coordinator: -

 

 

Project 11

Title: Systematic review on the prevention and treatment for major side effects of cancer 

and western therapies using acupuncture and /or Chinese herbal medicine

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: Hospital Authority of Hong Kong

Project ID: -

Exercise Year: 2009/2010

Approved Project Duration: -

Project Fund: HK$229,260

Coordinator: -

 

 

Project 12

Title: Nerve Growth Factor (NGF) Signaling in the generation and maintenance of 

colonic motility disorder induced by neonatal maternal separation

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: HKBU/FRG

Project ID: -

Exercise Year: 2009/2010

Approved Project Duration: -

Project Fund: HK $115,000

Coordinator: -

 

 

Project 13

Title: Altered Excitability of Voltage-gated K+ channels in DRG neurons contributes to neonatal

maternal separation-induced visceral hyperalgesia

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: HKBU/FRG

Project ID: -

Exercise Year: 2009/2010

Approved Project Duration: -

Project Fund: $40,000

Coordinator: -

 

 

Project 14

Title: Role of nerve growth factor signaling in the maintenance of visceral hyperalgesia in an 

animal model of irritable bowel syndrome (IBS)

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: General Research Fund (GRF1)

Project ID: -

Exercise Year: 2008/2010

Approved Project Duration: -

Project Fund: HK$:497,000

Coordinator: -

 

 

Project 15

Title: Toward Drug Development of JCICM-16-02 Formula for Irritable Bowel Syndrome

Principal Investigator: Prof BIAN Zhaoxiang

Funding Body: Hong Kong Jockey club   institute of Chinese Medicine Ltd

Project ID: ICM/4-7

Exercise Year: 2008/2010

Approved Project Duration: -

Project Fund: HK$7,348,000

Coordinator: -

 





1419913700697778.jpg


  Dr. Lin Chuhai (Ph.D.)

  Research Assistant Professor

  Mass Spectrometry

  Email: linroseshuhai@gmail.com









1419914081598351.jpg


  Dr. Sarwat Fatima (Ph.D.)

  Post-Doctoral Research Fellow

  Molecular Biology

  Email:sarwat@hkbu.edu.hk

 






  


1419915440744242.jpg


  Chenyuan Lin (Ph.D.)

  Post-Doctoral Research Fellow

  Molecular Endocrinology 

  Email: lincy@hkbu.edu.hk









1419915600153914.jpg


  Guoqing Chen

  Ph.D. Student

  Pharmacology and Toxicology

  Email: 12466859@life.hkbu.edu.hk









1419914747124093.jpg



  Ling Zhao

  Ph.D. Student

  Traditional Chinese Medicine

  Email: 14485400@hkbu.edu.hk









1.        

Tsang SW, Zhang HJ, Lin CY, Xiao HT, Wong M, Shang HC , Yang ZJ, Lu AP, Yung KKL, Bian ZX.   Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with chronic pancreatitis. Plos One, Under review. 

2.        

Witt CM, Aickin M, Cherkin D, Che CT, Elder C, Flower A, Hammerschlag R, Liu JP, Lao LX, Phurrough S, Ritenbaugh C, Rubin LH, Schnyer R, Wayne PM, Withers SR, Bian ZX, Young J, Berman BM. Effectiveness Guidance Document (EGD) for Chinese Medicine: A Consensus Document. BMJ. Under review. 

3.        

Lu A, Bensoussan A, Liu J, Bian Z, Cho WC. TCM Zheng Classification and Clinical Trials. Evid Based Complement Alternat Med. 2013;2013:723659. doi: 10.1155/2013/723659. Epub 2013 Aug 22.

4.        

Xiao HT, Tsang SW, Qin HY, Franky F.K. Choi, Yang ZY, Han QB, Chen HB, Xu HX, Sheng H, Lu AP, Bian   ZX*. A bioactivity guided study on the anti-diarrheal activity of Polygonum chinense Linn. J Ethnopharmacol, 2013 Sep 16;149(2):499-505. doi: 10.1016/j.jep.2013.07.007. Epub 2013 Jul 26. 

5.        

Zhang M, Zang KH, Luo JL, Leung FP, Huang Y, Lin CY, Bian ZX, Yang ZJ, Lu AP, Tang XD, Xu HX, Sung JJY. Magnolol inhibits colonic motility through down-regulation of voltage-sensitive L-type Ca2+ channels of colonic smooth muscle cells in rats. Phytomedicine, 2013 Aug 21. doi:pii: S0944-7113(13)00271-7.10.1016/j.phymed.2013.07.008. [Epub ahead of print]. 

6.        

Zhou WJ, Song JZ, Fu WW, Tan HS, Bian ZX, Xu HX. Chemical comparison of two dosage forms of Hemp Seed Pills by UHPLC-Q-ToF-MS/MS and multivariate statistical techniques. J Pharm Biomed Anal. 2013 Jun 3; 84C: 59-68. 

7.          

Zhong LL, Bian ZX, Gu JH, Zhou X, Tian Y, Mao JC, Chen XJ. Chinese Herbal Medicine (Zi Shen Qing) for Mild-to-Moderate Systematic Lupus Erythematosus: A Pilot Prospective, Single-Blinded, Randomized Controlled Study. Evid Based Complement Alternat   Med. 2013; 2013:327245. doi: 10.1155/2013/327245. Epub 2013 May 8.

8.        

Cheng CW, Fu SF, Zhou QH, Wu TX, Shang HC, Tang XD, Liu ZS, Liu J, Lin ZX, Lao L, Lü AP, Zhang BL, Liu BY, Bian ZX*. Extending the CONSORT Statement to moxibustion. J Integr Med., 2013, 11(1): 54-63.

9.        

Du B, Bian ZX, Xu B. Skin Health Promotion Effects of Natural   Beta-Glucan Derived from Cereals and Microorganisms: A Review. Phytother Res. 2013 Mar 11. doi: 10.1002/ptr.4963. 

10.    

Wang XG, Guo BS, Li Q, Peng J, Yang ZJ, Wang AY, Li D, Hou ZB, Lv K, Kan GH, Cao HQ, Wu H, Song JP, Pan XH, Sun Q, Ling SK, Li YH, Zhu M, Zhang PF, Peng SL, Xie XQ, Tang T, Hong A, Bian ZX, Bai YQ, Lu AP, Li YH, He FC, Zhang G, Li YX. miR-214 targets ATF4 to inhibit bone formation. Nat Med., 2013, Jan, 19(1): 93-100.

11.      

Cheng CW, Kwok AOL, Bian ZX, Tse DMW. A Cross Sectional Study of Constipation   and Laxatives Use in Advanced Cancer Patients: Insights for Revision of Current Practice. Support care Cancer, 2013, Jan, 21(1): 149-56. Epub 2012 Jun. 

12.      

Lu AP, Bian ZX, Chen KJ. Bridging the traditional Chinese medicine pattern classification and biomedical disease diagnosis with systems biology. Chin J Integr Med., 2012, 18(12): 883-90. Epub 2012 Dec 13. 

13.      

Li J, Lu C, Jiang M, Niu XY, Guo HT, Li L, Bian ZX, Lin N, Lu AP. Traditional Chinese medicine-based network pharmacology could lead to new multicompound drug discovery. Evid   Based Complement Alternat Med. 2012; 2012: 149762. doi: 10.1155/2012/149762.   Epub 2012 Dec 17.

14.      

Cheng CW, Kwok AOL, Bian ZX*, Tse DMW. The Quintessence of Traditional Chinese Medicine: Syndrome and Its Distribution among Advanced Cancer Patients with Constipation. Evid Based Complement Alternat Med. 2012; 2012: 739642. Epub 2012 Jun 24. 

15.        

Zhu GY, Wong BCK, Wong I, Bian ZX, Fong WF, Yang ZJ. Alkylphenols from the roots of Ardisia brevicaulis induce cell cycle arrest and apoptosis through endoplasmic reticulum stress pathway in human non-small-cell lung cancer cells, Chem Pharm Bull (Tokyo)., 2012, 60(8): 1029-36.

16.        

Bian ZX*. Novel insights about the mechanism of visceral   hypersensitivity in maternally separated rats. Neurogastroent & Motil,   2012; 2012 Jul, 24(7): 593-6. 

17.      

Liao W, Wei H, Wang XY, Qiu YP, Gou XJ, Zhang XL, Zhou MM, Wu JB, Wu T, Kou F, Zhang YY, Bian ZX, Xie GX, Jia W. Metabonomic Variations Associated with AOM-induced Precancerous Colorectal Lesions and Resveratrol Treatment. J Proteome Res., 2012, 11 (6): 3436–3448.

18.      

Zhang XJ, Choi FFK, Yan Z, Leung FP, Tan S, Lin SH, Xu HX, Jia W, Sung JJY, Cai ZW, Bian   ZX*. Metabolite   profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics. FEBS J., 2012, 279: 2322–2331.

19.      

Qin HY, Xiao HT, Leung FP, Wu JCY, Sung JJY, Xu HX, Tong XD, Bian ZX*. JCM-16021, a Chinese herbal formula, attenuated visceral hyperalgesia in TNBS-induced post-inflammatory irritable bowel syndrome rats through reducing   colonic EC cell hyperplasia and serotonin availability. Evid.-based Complement Altern. Med., 2012; 2012: 239638. Epub 2012 Jun 10.

20.      

Cheng CW, Kwok AOL, Bian ZX*, Tse DMW*. The Quintessence of Traditional Chinese Medicine: Syndrome and Its   Distribution among Advanced Cancer Patients with Constipation, Evid.-based   Complement Altern. Med., 2012; 2012: 739642. Epub 2012 Jun 24. 

21.      

Zhang  XJ, Leung FP, Hsiao WWL, Tan S, Li S, Xu HX, Sung JJY, Bian ZX*. Proteome profiling of spinal cord and DRG in rats with TNBS-induced colitis. World J Gastroenterol, 2012 Jun 21, 18(23): 2914-28.

22.      

Qin   HY, Xiao HT, WU JCY, Berman BM, Sung JJ, Bian ZX*. Key factors in developing TNBS-induced   Post-inflammatory Irritable Bowel Syndrome Model in Rats. World J Gastroenterol, 2012 May 28,18(20): 2481-92. 

23.      

Bian ZX*; Chen SL*, Chung CW, Wang J, Xiao HT, Qin HY. Developing new drugs from annals of Chinese medicine. Acta Pharmaceutica Sinica B., 2012 Feb 25, 2(1): 1-7.

24.      

Tian XY, Wong WT, Sayed N, Luo J, Tsang SY, Bian ZX, Lu Y, Cheang WS, Yao X, Chen ZY, Huang Y. NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel. Pharmacol Res., 2012 Feb: 65(2): 239-46. 

25.        

Wu T, Li Y, Zhen S, Deng S, Zhang L, Fan C, Jia W, Zhong Z, Du L, Liu X, Zhou Q, Xu Y, Chen K, Bian Z, Wong V. Joint statement   on promoting development of publication ethics among medical journals in   China. J Evid Based Med. 2011 Nov;4(4):214-216.

26.        

Zeng XX, Bian ZX*, Wu TX, Fu SF, Ziea E, Woon WT. Traditional Chinese Medicine Syndrome Distribution in Chronic Hepatitis B Populations: A Systematic Review. Am J Chin Med., 2011, 39(6): 1061-1074. 

27.      

Tsang SW, Bian ZX, Zhang XJ, Zhao   M. Nerve growth factor-mediated neuronal   plasticity in spinal cord contributes   to neonatal maternal separation-induced visceral hypersensitivity in rats. Eur J Pain., 2012 Apr: 16(4): 463-72. 

28.       

Bian ZX*, Qin HY, Tian SL, Qi SD. Combined effect of early life stress and acute stress on colonic sensory and motor responses through serotonin pathways: differences between proximal and distal colon in rats. Stress, 2011, 14(4): 448-58. 

29.      

Lin SH, Yang Z, Zhang XJ, Bian ZX, Cai ZW. Hippocampal metabolomics reveals 2, 3, 7, 8-tetrachlorodibenzo -p-dioxin toxicity associated with ageing in   SD rats. Talanta, 2011, 85(2): 1007-12. 

30.      

Luo JL, Qin HY, Wong CK, Tsang SY, Huang Y, Bian ZX*. Enhanced   Excitability and Down-Regulated Voltage - Gated Potassium   Channels in Colonic DRG Neurons from Neonatal Maternal Separation Rats. J Pain., 2011, May, 12(5): 600-9. 

31.     

Bian ZX*, Shang HC. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med., 2011, Feb 15, 154(4):290-1. 

32.     

Bian ZX*, Chang YH, Revised STRICTA as a extending the CONSORT Statement: More items should be involved in the   checklist. J Altern Complem Med., 2011, Feb, 17(2): 97-8.

33.      

Lau YT, Wong CK, Luo J, Leung LH, Tsang PF, Bian ZX, Tsang SY. Effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel   blockers on the proliferation and cell cycle progression of embryonic stem cells. Pflugers Arch., 2011, Jan, 461(1):191-202.

34.      

Cheng CW, Bian ZX*,   Zhu LX, Wu JC, Sung JJ. Efficacy of a Chinese herbal proprietary medicine (Hemp Seed Pill) for functional constipation. Am   J Gastroenterol., 2011, Jan, 106(1):120-9.

35.      

Qian HY, Tian XL, Wu J, Sung JJ,Xu HX, Bian ZX*. Systematic review of animal models of post-infectious/post inflammatory irritable. J Gastroenterol., 2011, 46: 164-174.

36.      

Qin HY, Luo JL, Qi SD, Xu HX,Sung JJY, Bian ZX*. Visceral hypersensitivity induced by activation of Transient Receptor Potential Vanilloid Type 1 is mediated through the serotonin pathway in rat colon. Eur J Pharmacol, 2010 Nov 25, 647(1-3):75-83. Epub 2010 Sep 6.

37.      

Bian ZX*, Cheung CW, Fan Y. Evidence-based Management of Herb-Drug Interaction in Cancer Chemotherapy. Explore-NY, 2010 Sep-Oct, 6(5): 324-9. 

38.        

Lau WK, Lau YM, Zhang HQ, Wong SC, Bian ZX. Electroacupuncture versus celecoxib for neuropathic pain in rat SNL model section: pain mechanisms and sensory neuroscience. Neuroscience, 2010, Oct 13, 170(2): 655-61. Epub 2010 Jul 25.

39.      

Wang L, Cui XH, Cheng L, Yuan Q, Li TQ, Li YP, Deng SL, Shang HC, Bian ZX. Adverse events to Houttuynia injection: A systematic review. J Evid Based   Med., 2010, Aug, 3(3): 168-76.

40.   

Bian ZX*. Wu TX. Legislation for trial registration and data transparency. Trials 2010 May 26, 11:64.

41.      

Bian ZX,Tian HY, Gao L, Shang HC, Wu TX, Li YP, Zhang BL, Song L.Improving reporting of adverse events and   adverse drug reactions following injections of Chinese materia medica, J Evid Based Med., 2010, 5-10.

42.      

Wu TX, Shang HC, Bian ZX, Zhang JH, Li TQ, Li YP, Zhang BL. Recommendations for reporting adverse drug reactions and adverse events of   traditional Chinese medicine. J Evid Based Med., 2010,11-17.

43.      

Bian ZX*, Shang HC, Wu TX, Li YP, Zhang BL. Review of adverse reactions to Chinese medicine injections. J Evid Based Med., 2010: 88-94.

44.        

Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX,Tsang SY. Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J Cell Physiol., 2010, Jul, 224(1): 165-77.

45.        

Zhang M, Leung FP, Huang Y, Bian ZX*. Increased colonic motility in a rat model of irritable bowel syndrome is associated with up-regulation of L-type calcium channels in colonic smooth muscle cells. Neurogastroent & Motil, 2010, 22(5): 162-70.

46.       

Bian ZX*, Zhang M, Hang QB, Xu HX, Sung JJY. Analgesic effects of JCM-16021 on neonatal maternal separation-induced visceral pain in rats. World J Gastroenterol, 2010, 16(7): 837-845.

47.      

Zhang HW, Bian ZX, Ling ZX. Are acupoints specific for diseases? A systematic review of the randomized controlled trials with sham acupuncture controls. Chin Med., 2010, 5:1.

 




Copyright ©2013 - 2015 Mr. and Mrs. Ko Chi Ming Centre for Parkinson’s Disease Research